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DiabetesIndia 2022: Hepatopancreatic Fat-Fetuin-A Based Axis for the Pathogenesis of Diabetes and its Reversal

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Dr Anoop Misra, New Delhi    10 July 2022

  • A number of studies have demonstrated a link between pancreatic fat and impaired glucose metabolism, as well as between pancreatic fat and T2DM.
  • In general, pancreatic volume decreases with age and in diabetes, while pancreatic fat increases with both.
  • Ethnic differences in pancreatic volume have been reported, while research in India is negligible.
  • Fetuin-A is a key metabolic regulator causing effects on the pancreas and multiple other tissues, and responsible for insulin resistance, hyperglycemia and (with palmitate) β-cell apoptosis.
  • Different approaches, such as a hypocaloric diet, exercise, bariatric surgery and pharmacological interventions, can reduce pancreatic fat content.
  • A decrease in pancreatic and hepatic fat and a decrease in fetuin-A (insulin resistance/inflammation) could lead to reversal of diabetes.

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